Morphological heterogeneity of intratumoral macrophages in prostate tumors

Background . Prostate cancer (PCa) is the most common human worldwide. In progression of prostate cancer, total number macrophages in tumor tissue associated with poor prognosis and increased risk metastasis. However, heterogeneity intratumoral at various stages PCa development, role tumor-associated (TAMs) have been insuffciently investigated. The aim study was to analyze morphological features, size TAMs samples, reveal their correlation clinical data patients. Material Methods Immunohistochemical analysis 36 paraffn blocks patients (pT2a–3bN0–1M0) performed using antibodies scavenger receptor CD68. Results Foamy CD68+ were found tissue. indicator “number per felds view macrophages” lowest a Gleason score 6 (5.8) (11.0 – ≥ 8). Macrophages formed larger clusters severe PCa. Small but not large signifcantly more lymph node metastases (48 vs 24 N0 group; p=0.14). small (smaller than 100 µm 2 ) series scores 6, 7 8 (24, 47.5, 72, respectively, p=0.052). Conclusion As process progressed biochemical recurrence increased, there trend towards an increase area large, foamy TAMs, presumably rich lipids, as well wider distribution tendency form clusters. We hypothesize that are involved further recruitment subsequently leading metastasis progression.